Immunology and immunopathology of African trypanosomiasis

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[Immunology and immunopathology of African trypanosomiasis].

Human African trypanosomiasis (HAT) is characterized by a major deregulation of the immune system. Hypergammaglobulinemia, auto-antibodies, and immunodepression are cardinal features. Parasitemia occurs in waves due to the successive appearance of parasites with different variable glycoprotein surface antigens (VGSA). Antigenic variation enables parasites to elude the host's immune defenses. Al...

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ژورنال

عنوان ژورنال: Anais da Academia Brasileira de Ciências

سال: 2006

ISSN: 0001-3765

DOI: 10.1590/s0001-37652006000400004